Gene Therapy Applications in Gastroenterology and Hepatology | Zendy

Catherine H. Wu | Zendy; Lanlan Shen | Zendy; George Y. Wu | Zendy

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Gene Therapy Applications in Gastroenterology and Hepatology

Author(s) -

Catherine H. Wu,

Lanlan Shen,

George Y. Wu

Publication year - 2000

Publication title -

canadian journal of gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 1916-7237

pISSN - 0835-7900

DOI - 10.1155/2000/959231

Subject(s) - ribozyme , genetic enhancement , hepatology , oligonucleotide , gene , vector (molecular biology) , gene delivery , viral vector , gene transfer , computational biology , virology , biology , medicine , bioinformatics , rna , genetics , recombinant dna

Advantages and disadvantages of viral vectors and nonviral vectors for gene delivery to digestive organs are reviewed. Advances in systems for the introduction of new gene expression are described, including self-deleting retroviral transfer vectors, chimeric viruses and chimeric oligonucleotides. Systems for inhibition of gene expression are discussed, including antisense oligonucleotides, ribozymes and dominant-negative genes.

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