Open AccessCingulate Abnormalities Associated with PANSS Negative Scores in First Episode Schizophrenia
Author(s) -
Liz Ashton,
Anna Barnes,
Martin Livingston,
David J. Wyper,
The Scottish Schizophrenia Research Group
Publication year - 2000
Publication title -
behavioural neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.859
H-Index - 48
eISSN - 1875-8584
pISSN - 0953-4180
DOI - 10.1155/2000/913731
Subject(s) - statistical parametric mapping , schizophrenia (object oriented programming) , psychology , medicine , verbal fluency test , statistical significance , positive and negative syndrome scale , clinical psychology , correlation , gyrus , psychosis , psychiatry , neuroscience , cognition , neuropsychology , magnetic resonance imaging , radiology , geometry , mathematics
There is evidence for the involvement of the cingulate gyrus in schizophrenia. We present details of a Statistical Parametric Mapping (SPM) analysis of SPECT data from the largest study (N = 39) of drug naive schizophrenic patients. The main findings are that there is decreased perfusion in the anterior cingulate during verbal fluency when patients are compared to controls (matched individually by age, gender and father's social class as determined by occupation) and also that PANSS negative scores correlate negatively with regional cerebral blood flow in the cingulate gyrus (Pearson's Correlation coefficient of r = - 0.49 and significance p< 0.005). This suggests that measurement of change of perfusion in this region could be a useful biological marker in assessing the effect of neuroleptics on negative symptoms.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom