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Sjogren’s Syndrome (SS) is an autoimmune disease characterized by chronic Band T-cell infiltration of the salivary and lachrymal glands. Clusters of Band Tcells which resemble germinal centres are seen within the glandular tissue. We have shown that clonal Bcell proliferation and affinity maturation are occurring within these clusters [1]. ScFv antibodies have been produced from one of these B-cell clusters to identify the autoantigen that induces a germinal centre reaction and study the effects of somatic hypermutation on the autoimmune response.

Application of ScFv-Phage Display to Analysis of B-Cell Clones Proliferating in the Salivary Glands of a Patient with Sjögren's Syndrome