A Second Family with Probable CRAC (Colorectal Adenomata and Carcinoma) Syndrome—A New Familial Cancer

Tomlinson et al. recently described a new familial cancer syndrome CRAC-1 (colorectal adenoma and carcinoma), with a phenotype characterised by bowel carcinoma with associated large colorectal polyps with a serrated adenoma histology [1]. Other cancers including pancreatic and renal and breast were described in the original SM1311 pedigree, although the authors were not sure if these were part of the tumour spectrum. We describe a similar family with virtually identical clinical features, suggesting a wider tumour spectrum is part of the CRAC phenotype.