The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors | Zendy

Alberto Varas | Zendy; Teresa Romo | Zendy; Eva Jiménez | Zendy; Luis Martı́nez Alonso | Zendy; Ángeles Vicente | Zendy; A. Zapata | Zendy

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The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors

Author(s) -

Alberto Varas,

Teresa Romo,

Eva Jiménez,

Luis Martı́nez Alonso,

Ángeles Vicente,

A. Zapata

Publication year - 1997

Publication title -

journal of immunology research

Language(s) - English

Resource type - Journals

eISSN - 2314-8861

pISSN - 2314-7156

DOI - 10.1155/1998/95861

Subject(s) - biology , progenitor cell , interleukin 2 , t cell , monoclonal antibody , receptor , progenitor , microbiology and biotechnology , il 2 receptor , lymphokine , endocrinology , medicine , immunology , antibody , immune system , stem cell , genetics

On the basis of both the interleukin-2-receptor (IL-2R) alpha-chain expression on 16-day-old fetal rat thymocytes and the occurrence of interleukin-2 (IL-2) mRNA-containing cells early during rat thymus ontogeny, we have investigated the possible role of IL-2/IL-2R complex in rat T-cell maturation. For this purpose, we analyzed the effects of the addition of either recombinant rat IL-2 or anti-CD25 (OX-39)-blocking monoclonal antibodies to fetal thymus organ cultures (FTOC), established from 16-day-old rat embryos. IL-2 stimulated the growth of thymocytes and, as a result, induced T-cell differentiation, whereas OX-39 mAb blocked the maturation of thymic-cell progenitors. Accordingly, these results support the involvement of IL-2/IL-2R complex in rat T-cell development.

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