Relationship between AgNOR Proteins, Ki-67 Antigen, p53 Immunophenotype and Differentiation Markers in Archival Breast Carcinomas | Zendy

Ágnes Bánkfalvi | Zendy; Klaus SchmitzAbe | Zendy; Tobias Mock | Zendy; Mechthild Kemper | Zendy; Christiane Cubick | Zendy; W. Böcker | Zendy

Open Access

Relationship between AgNOR Proteins, Ki-67 Antigen, p53 Immunophenotype and Differentiation Markers in Archival Breast Carcinomas

Author(s) -

Ágnes Bánkfalvi,

Klaus SchmitzAbe,

Tobias Mock,

Mechthild Kemper,

Christiane Cubick,

W. Böcker

Publication year - 1998

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/1998/760324

Subject(s) - nucleolus organizer region , pathology , immunohistochemistry , proliferation marker , biology , immunophenotyping , progesterone receptor , ki 67 , antigen , breast cancer , estrogen receptor , medicine , cancer , immunology , nucleolus , biochemistry , genetics , cytoplasm

The present study investigated (i) the relationship between standardised morphometric AgNOR parameters (argyrophilic nucleolar organiser region-associated proteins) and MIB1 growth fraction, and (ii) their correlation with immunohistochemical p53, sex steroid receptor status and histopathological differentiation grade in serial paraffin sections from 39 breast carcinomas. Ten sections were double-stained for AgNOR/MIB1. AgNOR parameters correlated significantly with MIB1 growth fraction and p53 protein expression. Significant inverse correlation was found between proliferation markers and oestrogen/progesterone receptor status and histopathological grade. AgNOR expression was significantly higher in cycling (MIB1 positive) tumour cells, than in resting (MIB1 negative) ones, however with exceptions. We conclude, that standardised AgNOR parameters correlate with markers of increased malignant potential in breast carcinomas. However, AgNORs seem to reflect proliferation independent cellular and nucleolar activity of tumour cells, as well. We recommend the use of standardised AgNOR analysis for obtaining sound results in routine paraffin sections.

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