A fast screening method for tricyclic antidepressants and their urinary metabolites by FAB-tandem mass spectrometry | Zendy

Mathias Schäfer | Zendy; H. Budzikiewicz | Zendy; H. Brzezinka | Zendy; M. Schifferdecker | Zendy

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A fast screening method for tricyclic antidepressants and their urinary metabolites by FAB-tandem mass spectrometry

Author(s) -

Mathias Schäfer,

H. Budzikiewicz,

H. Brzezinka,

M. Schifferdecker

Publication year - 1997

Publication title -

journal of spectroscopy

Language(s) - English

Resource type - Journals

eISSN - 2314-4920

pISSN - 2314-4939

DOI - 10.1155/1997/823624

Subject(s) - chemistry , chromatography , nortriptyline , tricyclic , desipramine , mass spectrometry , tandem mass spectrometry , urine , imipramine , glucuronide , amitriptyline , stereochemistry , pharmacology , medicine , antidepressant , biochemistry , alternative medicine , pathology , hippocampus

A screening method for tricyclic antidepressants (TCA) and their urinary metabolites by FAB tandem mass spectrometry (FAB MS/MS) is presented. The collision induced dissociation (CID) behavior of pure dibenzocycloheptadienes (amitriptyline 1, nortriptyline 2), dibenzoxepines (doxepine 3, dosulepine 4), dibenzazepines (imipramine 5, desipramine 6, trimipramine 7) and the iminostilbene derivative opipramol 8 is described and used for the specific determination of these tricyclics by MS/MS.

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