Clinical, Pathological and Molecular Genetic Findings in Small Intestinal Follicle Centre Cell Lymphoma | Zendy

Hugh James Freeman | Zendy; Michelle E. Anderson | Zendy; Randy D. Gascoyne | Zendy

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Clinical, Pathological and Molecular Genetic Findings in Small Intestinal Follicle Centre Cell Lymphoma

Author(s) -

Hugh James Freeman,

Michelle E. Anderson,

Randy D. Gascoyne

Publication year - 1997

Publication title -

canadian journal of gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 1916-7237

pISSN - 0835-7900

DOI - 10.1155/1997/507318

Subject(s) - pathology , lymphoma , follicular lymphoma , immunophenotyping , small intestine , biopsy , pathological , gene rearrangement , biology , chromosomal translocation , gastrointestinal tract , malt lymphoma , medicine , gene , immunology , antigen , biochemistry

A 44-year-old male was evaluated for an iron deficiency anemia. Endoscopic investigation revealed marked serpiginous ulceration of the proximal small intestine due to a B cell lymphoma. Endoscopic small intestinal mucosal biopsies revealed a nodular lymphoid infiltrate, and polymerase chain reaction of biopsy material from the same site demonstrated rearrangement of the bcl-2 gene, the molecular equivalent of the t(14;18) chromosomal translocation. Primary small bowel follicular small cleaved cell lymphoma was diagnosed. Endoscopic tissue biopsies for immunophenotyping, molecular genetic studies or both are a valuable diagnostic aid for precise classification of lymphoid neoplasms in the gastrointestinal tract.

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