Cholestasis in Crohn's Disease: A Diagnostic Challenge | Zendy

Nir Hilzenrat | Zendy; Esther Lamoureux | Zendy; Averell H. Sherker | Zendy; Albert Cohen | Zendy

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Cholestasis in Crohn's Disease: A Diagnostic Challenge

Author(s) -

Nir Hilzenrat,

Esther Lamoureux,

Averell H. Sherker,

Albert Cohen

Publication year - 1997

Publication title -

canadian journal of gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 1916-7237

pISSN - 0835-7900

DOI - 10.1155/1997/203843

Subject(s) - medicine , sulfasalazine , exacerbation , cholestasis , gastroenterology , inflammatory bowel disease , disease , liver disease , liver biopsy , colitis , rifaximin , hepatitis , biopsy , ulcerative colitis , antibiotics , microbiology and biotechnology , biology

A 24-year-old male with Crohn's disease who developed three independent episodes of cholestatic liver disease over an eight-year period is described. The first episode was related to an idiosyncratic drug reaction while on sulfasalazine. The second episode, at the time of an exacerbation of his colitis, was characterized by moderate portal inflammation on liver biopsy and resolved quickly while he was on corticosteroid therapy. The most recent episode, occurring when the bowel disease was quiescent, was due to granulomatous hepatitis and resolved clinically with no specific therapy. Because numerous potentially serious hepatobiliary complications have been associated with inflammatory bowel disease, prompt and aggressive investigation in these instances is recommended.

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