Adherence ofHelicobacter pylorito the Gastric Mucosa | Zendy

Marguerite Clyne | Zendy; Brendan Drumm | Zendy

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Adherence ofHelicobacter pylorito the Gastric Mucosa

Author(s) -

Marguerite Clyne,

Brendan Drumm

Publication year - 1997

Publication title -

canadian journal of gastroenterology and hepatology

Language(s) - English

Resource type - Journals

eISSN - 2291-2797

pISSN - 2291-2789

DOI - 10.1155/1997/149734

Subject(s) - helicobacter pylori , gastric mucosa , gastritis , bacterial adhesin , pathogenesis , pathogen , virulence , medicine , epithelium , disease , immunology , microbiology and biotechnology , biology , gastroenterology , stomach , pathology , gene , genetics

Bacterial adhesion to the intestinal epithelium is a critical initial step in the pathogenesis of many enteric diseases. Helicobacter pylori is a duodenal pathogen that adheres to the gastric epithelium and causes gastritis and peptic ulceration. The mechanism by which H pylori causes disease has not been elucidated but adherence to the gastric mucosa is thought to be an important virulence determinant of the organism. What is known about adherence of H pylori to the gastric mucosa is summarized. Topics discussed are the mechanism of H pylori adherence; in vitro and in vivo models of H pylori infection; and adherence and potential adhesins and receptors for H pylori.

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