Monocyte and Blood Interleukin-12 Levels Patients with Obstructive Jaundice | Zendy

Wen G. Jiang | Zendy; M. C. A. Puntis | Zendy

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Monocyte and Blood Interleukin-12 Levels Patients with Obstructive Jaundice

Author(s) -

Wen G. Jiang,

M. C. A. Puntis

Publication year - 1996

Publication title -

hpb surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.561

H-Index - 26

eISSN - 1607-8462

pISSN - 0894-8569

DOI - 10.1155/1996/96426

Subject(s) - medicine , obstructive jaundice , jaundice , gastroenterology , immune system , monocyte , incidence (geometry) , cellular immunity , immunity , interleukin , liver dysfunction , interleukin 6 , mann–whitney u test , immunology , cytokine , physics , optics

Patients with obstructive jaundice have an increased incidence of peri-operative complications and immune dysfunction. This study was to investigate interleukin (IL)-12 (a cellular immunity stimulant), levels in jaundiced patients. 23 jaundiced patients and 17 controls were studied. There was significantly increased monocyte IL-12 production in jaundice, as measured by an ELISA, compared with that in controls (p < 0.01 by Mann-Whitney U test). A similar increase is seen in both benign and malignant jaundice. There was no difference between plasma IL-12 levels in the two groups. It is concluded that in jaundice, monocytes have a significantly increased capacity to release IL-12. This suggests that IL-12 may play a role in the immune dysfunction in jaundiced patients.

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