Improvement of Rat Survival and Liver Mitochondrial Function in Biliary Obstruction After Treatment With Sodium Thiosulfate | Zendy

B. Myslovaty | Zendy; S. Kyzer | Zendy; H. Levinsky | Zendy; C Chaimoff | Zendy

Open Access

Improvement of Rat Survival and Liver Mitochondrial Function in Biliary Obstruction After Treatment With Sodium Thiosulfate

Author(s) -

B. Myslovaty,

S. Kyzer,

H. Levinsky,

C Chaimoff

Publication year - 1995

Publication title -

hpb surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.561

H-Index - 26

eISSN - 1607-8462

pISSN - 0894-8569

DOI - 10.1155/1995/43679

Subject(s) - sodium thiosulfate , medicine , liver function , jaundice , gastroenterology , mitochondrion , survival rate , liver function tests , biochemistry , chemistry , inorganic chemistry

The exact cause of liver failure occurring after long standing biliary obstruction is not known. Impairment of hepatic mitochondrial respiration was postulated in some studies. Sodium thiosulphate (STS) is known to have a protective effect on liver function during administration of hepatotoxic chemotherapy. In the present experimental study the effect of treatment with STS in the presence of obstructive jaundice was studied by determination of the survival rate of rats subjected to biliary obstruction and by polarographic determination of the hepatic mitochondrial function. Treatment with STS was found to result in a significant improvement in rats' survival rate (p < 0.05). Polarography demonstrated significant preservation of mitochondrial respiratory capacity after treatment with STS. The results of the present study show that the deterioration in liver function in the presence of biliary obstruction is probably caused by impairment of mitochondrial respiration. This may be preserved by treatment with STS. The exact explanation of its effect is not yet clear.

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