The Canadian Multicentre MAC Treatment Study | Zendy

Stephen D. Shafran | Zendy; The Canadian HIV Trials Network | Zendy

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The Canadian Multicentre MAC Treatment Study

Author(s) -

Stephen D. Shafran,

The Canadian HIV Trials Network

Publication year - 1994

Publication title -

canadian journal of infectious diseases and medical microbiology

Language(s) - English

Resource type - Journals

eISSN - 1918-1493

pISSN - 1712-9532

DOI - 10.1155/1994/475109

Subject(s) - medicine , clinical trial , regimen , human immunodeficiency virus (hiv) , mycobacterium avium complex , intensive care medicine , disease , clinical research , drug , antimycobacterial , family medicine , pharmacology , tuberculosis , pathology , mycobacterium tuberculosis

Mycobacierium avium complex (MAC) infeclion is a common complication of the advanced stages of human immunodeficiency virus (HIV) infectioncausing both morbidity and premature mortality. While it is acknowledged thal MAC infection requires treatment with a combination of antimycobacterial drugs. the optimal regimen has not been defined. A Canadian Multicentre MAC Treatment Trial was proposed in 1990 and finally implemented in late 1992 via the Canadian HIV Trials Network with the assistance of 6 pharmaceutical companies. The specific drug regimens and study design are outlined and the timetable for analysis and completion are also indicated.Collaborative, Canadian, multicentre clinical trials in HIV disease can be successfully implemented

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