The Role of the Caudate in Nonmotor Behaviors in Huntington’s Disease | Zendy

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The Role of the Caudate in Nonmotor Behaviors in Huntington’s Disease

Author(s) -

Daniel Jacobs,

S. J. Huber

Publication year - 1992

Publication title -

behavioural neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.859

H-Index - 48

eISSN - 1875-8584

pISSN - 0953-4180

DOI - 10.1155/1992/926819

Subject(s) - psychology , basal ganglia , caudate nucleus , neuroscience , huntington's disease , disconnection , amygdala , disease , cognitive psychology , central nervous system , medicine , pathology , political science , law

Neuropsychologic data suggest an important role for the caudate nucleus (CN) in behavioral impairments in Huntington's disease (HD). These include abnormalities in executive function, egocentric visuospatial representations, communication, and retrieval of declarative memories, changes in personality, and psychiatric disturbances. Animal paradigms of CN lesions support a role for the CN in some of these behaviors. Current theories of basal ganglia function add explanatory value to the role of the CN in these behaviors. A disconnection of the caudate from limbic structures, including the amygdala may account for many nonmotor behaviors observed in HD.

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