Induction of Apoptosis in Thymocytes by Prostaglandin E2 In Vivo | Zendy

Antonio Mastino | Zendy; Mauro Piacentini | Zendy; Sandro Grelli | Zendy; Cartesio Favalli | Zendy; Francesco Autuori | Zendy; Lucio Tentori | Zendy; Serafina Oliverio | Zendy; Enrico Garach | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Induction of Apoptosis in Thymocytes by Prostaglandin E2 In Vivo

Author(s) -

Antonio Mastino,

Mauro Piacentini,

Sandro Grelli,

Cartesio Favalli,

Francesco Autuori,

Lucio Tentori,

Serafina Oliverio,

Enrico Garach

Publication year - 1992

Publication title -

journal of immunology research

Language(s) - English

Resource type - Journals

eISSN - 2314-8861

pISSN - 2314-7156

DOI - 10.1155/1992/80863

Subject(s) - cd8 , prostaglandin e2 , apoptosis , in vivo , intracellular , microbiology and biotechnology , biology , endogeny , tissue transglutaminase , thymocyte , receptor , cd3 , prostaglandin , t cell receptor , t cell , endocrinology , medicine , immunology , immune system , biochemistry , enzyme , genetics

In vivo administration in mice of a synthetic analog of prostaglandin E2 (PGE2) caused a selective and dramatic decrease of CD4+CD8+ double-positive, CD3/T-cell-receptor-alpha beta(lo) cells in the thymus. This loss was corticosteroid-independent and not affected by Cyclosporin A. The disappearance of CD4+CD8+ thymocytes was strictly correlated with the induction of apoptosis inside the thymus as shown by morphological studies and by the induction of intracellular transglutaminase expression. Considering that PGE2 has been found to be produced by different cell populations inside the thymus, these results indicate that PGE2 may act as endogenous signals for apoptosis during T-cell differentiation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research