In Vitro Activities of Sparfloxacin, Ceftriaxone, Penicillin, Tetracycline and Doxycycline againstChlamydia trachomatisandNeisseria gonhorrhoeae | Zendy

H Talbot | Zendy; Barbara Romanowski | Zendy

Open Access

In Vitro Activities of Sparfloxacin, Ceftriaxone, Penicillin, Tetracycline and Doxycycline againstChlamydia trachomatisandNeisseria gonhorrhoeae

Author(s) -

H Talbot,

Barbara Romanowski

Publication year - 1992

Publication title -

canadian journal of infectious diseases and medical microbiology

Language(s) - English

Resource type - Journals

eISSN - 1918-1493

pISSN - 1712-9532

DOI - 10.1155/1992/743419

Subject(s) - neisseria gonorrhoeae , microbiology and biotechnology , penicillin , chlamydia trachomatis , tetracycline , sparfloxacin , ceftriaxone , doxycycline , minimum inhibitory concentration , antibiotics , neisseria , biology , chemistry , virology , bacteria , ofloxacin , ciprofloxacin , genetics

In vitro sparfloxacin was highly active against 223 penicillin-susceptible isolates of Neisseria gonorrhoeae with a 90% minimal inhibitory concentration (MIC90) of 0.004 μg/mL. Resistant strains of N gonorrhoeae totalled 55; 32 were penicillinase-producing and 23 chromosomally resistant. The MIC90 for these isolates was 0.004 μg/mL and 0.008 μg/mL, respectively. Chlamydia trachomatis was also very susceptible with an MIC50 of 0.063 μg/mL and a 50% minimal bactericidal concentration of 0.032 μg/mL for 11 isolates

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