Carcinogenesis in Chronic Ulcerative Colitis: Flow Cytometry | Zendy

Ahnen Dj | Zendy; J.B. Duke McHugh | Zendy; JM Bozdech | Zendy; GH Warren | Zendy

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Carcinogenesis in Chronic Ulcerative Colitis: Flow Cytometry

Author(s) -

Ahnen Dj,

J.B. Duke McHugh,

JM Bozdech,

GH Warren

Publication year - 1990

Publication title -

canadian journal of gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 1916-7237

pISSN - 0835-7900

DOI - 10.1155/1990/981048

Subject(s) - ulcerative colitis , aneuploidy , flow cytometry , colorectal cancer , medicine , cancer , dysplasia , carcinogenesis , oncology , immunology , biology , genetics , disease , gene , chromosome

Flow cytometry is a conceptually straightforward quantitativemethod that can be used to determine the DNA content (and many otherparameters) of individual cells. It has been used in chronic ulcerative colitis toevaluate the presence of aneuploidy as a marker of colon cancer risk. In this paper,the basic principles of flow cytometry are reviewed, the current status of publishedstudies using flow cytometric analysis of DNA content in chronic ulcerativecolitis outlined, conclusions from the research are proposed and future researchneeds identified. Overall, aneuploidy correlates with the current best markers ofcancer risk in ulcerative colitis, ie, dysplasia and established cancer. Whetheraneuplo1dy will be useful for the prospective identification of individuals atincreased risk for colon cancer deserves rigorous evaluation. An importanttechnical issue of potential variability in interpretation of near diploid peaks isemphasized

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