Open AccessBudesonide Enemas for Topical Therapy of Ulcerative Colitis
Author(s) -
Paul Rutgeerts
Publication year - 1990
Publication title -
canadian journal of gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 1916-7237
pISSN - 0835-7900
DOI - 10.1155/1990/583849
Subject(s) - budesonide , ulcerative colitis , medicine , enema , gastroenterology , colitis , placebo , corticosteroid , pathology , disease , alternative medicine
Budesonide is a nonhalogenated glucocorticosteroid that is verysuitable for topical therapy in left-sided colitis because it has a high ratio of topicalto systemic activity. Although it is absorbed, it is very rapidly metabolized by theliver (first pass metabolism). It does not suppress the hypothalamic-pituitary axis.Budesonide has been shown to be more effective than placebo and predinsoloneenemas for the treatment of left-sided ulcerative colitis
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