Pregnancy and the Biliary System | Zendy

Helga Witt | Zendy; J. J. Con | Zendy

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Pregnancy and the Biliary System

Author(s) -

Helga Witt,

J. J. Con

Publication year - 1990

Publication title -

canadian journal of gastroenterology and hepatology

Language(s) - English

Resource type - Journals

eISSN - 2291-2797

pISSN - 2291-2789

DOI - 10.1155/1990/582650

Subject(s) - chenodeoxycholic acid , gallstones , pregnancy , gallbladder , medicine , cholecystitis , cholesterol , bile acid , contractility , gastroenterology , estrogen , cholic acid , estrogen therapy , endocrinology , biology , genetics

Alterations in the synthesis and secretion of bile salts andcholesterol and in gallbladder function occur during pregnancy. These changesare related to the effects of estrogen and progesterone. Biliary cholesterol saturationand the cholic acid/chenodeoxycholic acid ratio increase. Progesterone alsodiminishes gallbladder contractility and emptying. Gallstones occur in 2.5 to11% of pregnant women and are associated with cholecystitis in 0.008 to 0.1%of pregnant women. Operative treatment should be deferred if possible until afterdelivery; failing that, surgery is best done in the second trimester. Endoscopicpap1llotomy may prove to be the best therapy for choledocholithiasis

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