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Collagenous colitis is a clinicopathologic syndrome which presentsas chronic, watery, nonbloody diarrhea. Colonic biopsies characteristicallyshow a thick subepithelial collagen band. Barium enema and colonoscopygenerally fail to establish the diagnosis. This case report provides evidence forhistologic progression over time, pancolonic involvement and the presence ofextraintestinal features of collagenous colitis. The reported patient showed noresponse to 5-aminosalicylic acid. Colonoscopic biopsies in cases of chronicdiarrhea can save the patient repeated, uncomfortable and costly investigations

Collagenous Colitis: Histologic Progression, Extraintestinal Features and Lack of Response to 5-ASA - A Case Report