Absence of Effect of Somatostatin Analogue (SMS 201-995) in Diarrhea Associated with Inflammatory Bowel Disease | Zendy

Richard N. Fedorak | Zendy; Richard W. Sherbaniuk | Zendy

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Absence of Effect of Somatostatin Analogue (SMS 201-995) in Diarrhea Associated with Inflammatory Bowel Disease

Author(s) -

Richard N. Fedorak,

Richard W. Sherbaniuk

Publication year - 1989

Publication title -

canadian journal of gastroenterology and hepatology

Language(s) - English

Resource type - Journals

eISSN - 2291-2797

pISSN - 2291-2789

DOI - 10.1155/1989/525713

Subject(s) - diarrhea , somatostatin , inflammatory bowel disease , medicine , gastroenterology , short bowel syndrome , ileostomy , crohn's disease , somatostatin analogue , endocrinology , disease , octreotide , parenteral nutrition

The octapeptide long acting somatostatin analogue, SMS 201-995promotes intestinal fluid and electrolyte absorption and inhibits anion secretion.It is more potent than native somatostatin and does not exhibit tachyphylaxsis.SMS 201-995 was used to treat two patients with severe diarrhea associated withCrohn’s disease after other treatments had failed. The volume and frequency ofileostomy output in one patient and stool output in the other did not respond totherapy with SMS 201-995. ln fact, diarrhea appeared to increase in both patientswhile on treatment

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