Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches | Zendy

Julia Beermann | Zendy; Maria-Teresa Piccoli | Zendy; Janika Viereck | Zendy; Thomas Thum | Zendy

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Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches

Author(s) -

Julia Beermann,

Maria-Teresa Piccoli,

Janika Viereck,

Thomas Thum

Publication year - 2016

Publication title -

physiological reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 13.853

H-Index - 342

eISSN - 1522-1210

pISSN - 0031-9333

DOI - 10.1152/physrev.00041.2015

Subject(s) - microrna , biogenesis , long non coding rna , computational biology , biology , rna , non coding rna , coding (social sciences) , disease , bioinformatics , genetics , gene , medicine , statistics , mathematics , pathology

Advances in RNA-sequencing techniques have led to the discovery of thousands of non-coding transcripts with unknown function. There are several types of non-coding linear RNAs such as microRNAs (miRNA) and long non-coding RNAs (lncRNA), as well as circular RNAs (circRNA) consisting of a closed continuous loop. This review guides the reader through important aspects of non-coding RNA biology. This includes their biogenesis, mode of actions, physiological function, as well as their role in the disease context (such as in cancer or the cardiovascular system). We specifically focus on non-coding RNAs as potential therapeutic targets and diagnostic biomarkers.

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