Open AccessClaudins and the Modulation of Tight Junction Permeability
Author(s) -
Dorothee Günzel,
Alan S.L. Yu
Publication year - 2013
Publication title -
physiological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 13.853
H-Index - 342
eISSN - 1522-1210
pISSN - 0031-9333
DOI - 10.1152/physrev.00019.2012
Subject(s) - claudin , tight junction , paracellular transport , permeability (electromagnetism) , microbiology and biotechnology , occludin , chemistry , biophysics , biology , membrane , biochemistry
Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability. This review summarizes our current knowledge of this large protein family and discusses recent advances in our understanding of their structure and physiological functions.
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