miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma | Zendy

Paige E. Bennett | Zendy; Lynne Bemis | Zendy; David A. Norris | Zendy; Yiqun G. Shellman | Zendy

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miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma

Author(s) -

Paige E. Bennett,

Lynne Bemis,

David A. Norris,

Yiqun G. Shellman

Publication year - 2013

Publication title -

physiological genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.078

H-Index - 112

eISSN - 1531-2267

pISSN - 1094-8341

DOI - 10.1152/physiolgenomics.00116.2013

Subject(s) - microrna , melanoma , biology , cancer , cancer research , skin cancer , gene , computational biology , bioinformatics , genetics

Melanoma is a very aggressive skin cancer with increasing incidence worldwide. MicroRNAs are small, noncoding RNAs that regulate gene expression of targeted gene(s). The hallmark of cancer model outlined by Hanahan and Weinberg offers a meaningful framework to consider the roles of microRNAs in melanoma development and progression. In this systematic review of the literature, we associate what is known about deregulation of microRNAs and their targeted genes in melanoma development with the hallmarks and characteristics of cancer. The diagnostic and therapeutic potential of microRNAs for future melanoma management will also be discussed.

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