Medial prefrontal cortex in neurological diseases | Zendy

Pan Xu | Zendy; Ai Chen | Zendy; Yipeng Li | Zendy; Xuezhi Xing | Zendy; Hui Lü | Zendy

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Medial prefrontal cortex in neurological diseases

Author(s) -

Pan Xu,

Ai Chen,

Yipeng Li,

Xuezhi Xing,

Hui Lü

Publication year - 2019

Publication title -

physiological genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.078

H-Index - 112

eISSN - 1531-2267

pISSN - 1094-8341

DOI - 10.1152/physiolgenomics.00006.2019

Subject(s) - prefrontal cortex , neuroscience , schizophrenia (object oriented programming) , autism , anxiety , disease , depression (economics) , psychology , autism spectrum disorder , addiction , cognition , psychiatry , medicine , pathology , economics , macroeconomics

The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process, regulation of emotion, motivation, and sociability. Dysfunction of the mPFC has been found in various neurological and psychiatric disorders, such as depression, anxiety disorders, schizophrenia, autism spectrum disorders, Alzheimer’s disease, Parkinson’s disease, and addiction. In the present review, we summarize the preclinical and clinical studies to illustrate the role of the mPFC in these neurological diseases.

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