Protein Homeostasis at the Plasma Membrane | Zendy

Pirjo M. Apaja | Zendy; Gergely L. Lukács | Zendy

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Protein Homeostasis at the Plasma Membrane

Author(s) -

Pirjo M. Apaja,

Gergely L. Lukács

Publication year - 2014

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00058.2013

Subject(s) - endosome , endocytic cycle , homeostasis , microbiology and biotechnology , membrane , membrane protein , chemistry , transport protein , biology , biochemistry , endocytosis , cell , intracellular

The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving cellular protein homeostasis in health and diseases.

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