How Do Kidneys Adapt to a Deficit or Loss in Nephron Number? | Zendy

Hadi Fattah | Zendy; Anita T. Layton | Zendy; Volker Vallon | Zendy

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How Do Kidneys Adapt to a Deficit or Loss in Nephron Number?

Author(s) -

Hadi Fattah,

Anita T. Layton,

Volker Vallon

Publication year - 2019

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00052.2018

Subject(s) - nephron , biology , kidney , microbiology and biotechnology , endocrinology , medicine , physiology

A deficit or loss in the number of nephrons, the functional unit of the kidney, can induce compensatory growth and hyperfunction of remaining nephrons. An increase in single nephron glomerular filtration rate (SNGFR) aims to compensate but may be deleterious in the long term. The increase in SNGFR is determined by the dynamics of nephron loss, total remaining GFR, the body’s excretory demand, and the functional capacity to sustain single nephron hyperfunction.

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