Airway Innervation and Plasticity in Asthma | Zendy

Loes Kistemaker | Zendy; Y. S. Prakash | Zendy

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Airway Innervation and Plasticity in Asthma

Author(s) -

Loes Kistemaker,

Y. S. Prakash

Publication year - 2019

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00050.2018

Subject(s) - airway , neuroscience , context (archaeology) , asthma , efferent , plasticity , biology , neuroplasticity , afferent , neurotrophin , medicine , immunology , receptor , anesthesia , paleontology , physics , thermodynamics , biochemistry

Airway nerves represent a mechanistically and therapeutically important aspect that requires better highlighting in the context of diseases such as asthma. Altered structure and function (plasticity) of afferent and efferent airway innervation can contribute to airway diseases. We describe established anatomy, current understanding of how plasticity occurs, and contributions of plasticity to asthma, focusing on target-derived growth factors (neurotrophins). Perspectives toward novel treatment strategies and future research are provided.

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