Residual Force Enhancement Following Eccentric Contractions: A New Mechanism Involving Titin | Zendy

Walter Herzog | Zendy; Gudrun SchappacherTilp | Zendy; Michael DuVall | Zendy; T.R. Leonard | Zendy; Jens Herzog | Zendy

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Residual Force Enhancement Following Eccentric Contractions: A New Mechanism Involving Titin

Author(s) -

Walter Herzog,

Gudrun SchappacherTilp,

Michael DuVall,

T.R. Leonard,

Jens Herzog

Publication year - 2016

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00049.2014

Subject(s) - titin , eccentric , mechanism (biology) , contraction (grammar) , muscle contraction , biophysics , materials science , sarcomere , structural engineering , medicine , anatomy , physics , myocyte , biology , engineering , quantum mechanics

Eccentric muscle properties are not well characterized by the current paradigm of the molecular mechanism of contraction: the cross-bridge theory. Findings of force contributions by passive structural elements a decade ago paved the way for a new theory. Here, we present experimental evidence and theoretical support for the idea that the structural protein titin contributes to active force production, thereby explaining many of the unresolved properties of eccentric muscle contraction.

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