Transcriptional Dysregulation of Adipose Tissue Autophagy in Obesity | Zendy

Nitzan Maixner | Zendy; Sapir Bechor | Zendy; Zlata Vershinin | Zendy; Tal Pecht | Zendy; Nir Goldstein | Zendy; Yulia Haim | Zendy; Assaf Rudich | Zendy

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Transcriptional Dysregulation of Adipose Tissue Autophagy in Obesity

Author(s) -

Nitzan Maixner,

Sapir Bechor,

Zlata Vershinin,

Tal Pecht,

Nir Goldstein,

Yulia Haim,

Assaf Rudich

Publication year - 2016

Publication title -

physiology

Language(s) - English

Resource type - Journals

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00048.2015

Subject(s) - autophagy , adipose tissue , pathogenesis , biology , downregulation and upregulation , obesity , disease , microbiology and biotechnology , gene , dysfunctional family , bioinformatics , genetics , immunology , medicine , endocrinology , apoptosis , clinical psychology

There is growing interest in understanding how dysregulated autophagy may contribute to pathogenesis of disease. Most frequently, disease states are associated with diminished autophagy, mostly attributed to genetic variation in autophagy genes and/or to dysfunctional posttranscriptional mechanisms. In human adipose tissue (AT), in obesity, expression of autophagy genes is upregulated and autophagy is likely activated, associating with adipose dysfunction. This review explores the emerging role of transcriptional mechanisms regulating AT autophagy in obesity.

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