Open AccessViewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy
Author(s) -
Valerie Sapp,
Mohit Jain,
Ronglih Liao
Publication year - 2016
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00047.2015
Subject(s) - proteotoxicity , pathogenesis , cardiomyopathy , amyloid (mycology) , protein aggregation , biology , microbiology and biotechnology , medicine , pathology , immunology , heart failure
Proteotoxicity refers to toxic stress caused by misfolded proteins of extrinsic or intrinsic origin and plays an integral role in the pathogenesis of cardiovascular diseases. Herein, we provide an overview of the current understanding of mechanisms underlying proteotoxicity and its contribution in the pathogenesis of amyloid cardiomyopathy.
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