Phosphodiesterases Maintain Signaling Fidelity via Compartmentalization of Cyclic Nucleotides | Zendy

Oliver Lomas | Zendy; Manuela Zaccolo | Zendy

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Phosphodiesterases Maintain Signaling Fidelity via Compartmentalization of Cyclic Nucleotides

Author(s) -

Oliver Lomas,

Manuela Zaccolo

Publication year - 2014

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00040.2013

Subject(s) - compartmentalization (fire protection) , phosphodiesterase , tolerability , nucleotide , microbiology and biotechnology , cyclic nucleotide , biology , neuroscience , chemistry , biochemistry , pharmacology , enzyme , gene , adverse effect

Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments.

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