Calcium, Reactive Oxygen Species, and Synaptic Plasticity | Zendy

Cecilia Hidalgo | Zendy; Alejandra AriasCavieres | Zendy

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Calcium, Reactive Oxygen Species, and Synaptic Plasticity

Author(s) -

Cecilia Hidalgo,

Alejandra AriasCavieres

Publication year - 2016

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00038.2015

Subject(s) - calcium , reactive oxygen species , synaptic plasticity , plasticity , biology , oxygen , chemistry , biochemistry , materials science , receptor , organic chemistry , composite material

In this review article, we address how activity-dependent Ca(2+)signaling is crucial for hippocampal synaptic/structural plasticity and discuss how changes in neuronal oxidative state affect Ca(2+)signaling and synaptic plasticity. We also analyze current evidence indicating that oxidative stress and abnormal Ca(2+)signaling contribute to age-related synaptic plasticity deterioration.

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