The Link Between Adipose Tissue Renin-Angiotensin-Aldosterone System Signaling and Obesity-Associated Hypertension | Zendy

Monica T.J. Schütten | Zendy; Alfons J.H.M. Houben | Zendy; Peter W. de Leeuw | Zendy; Coen D.A. Stehouwer | Zendy

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The Link Between Adipose Tissue Renin-Angiotensin-Aldosterone System Signaling and Obesity-Associated Hypertension

Author(s) -

Monica T.J. Schütten,

Alfons J.H.M. Houben,

Peter W. de Leeuw,

Coen D.A. Stehouwer

Publication year - 2017

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00037.2016

Subject(s) - adipose tissue , renin–angiotensin system , aldosterone , medicine , endocrinology , obesity , pathophysiology of hypertension , angiotensin ii , blood pressure

Obese individuals frequently develop hypertension, which is for an important part attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review summarizes preclinical and clinical evidence on the involvement of dysfunctional adipose tissue in RAAS activation and on the renal, central, and vascular mechanisms linking RAAS components to obesity-associated hypertension.

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