Mitophagy in Cardiomyocytes and in Platelets: A Major Mechanism of Cardioprotection Against Ischemia/Reperfusion Injury | Zendy

Weilin Zhang | Zendy; Chuyan Chen | Zendy; Jun Wang | Zendy; Lei Liu | Zendy; Yubin He | Zendy; Quan Chen | Zendy

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Mitophagy in Cardiomyocytes and in Platelets: A Major Mechanism of Cardioprotection Against Ischemia/Reperfusion Injury

Author(s) -

Weilin Zhang,

Chuyan Chen,

Jun Wang,

Lei Liu,

Yubin He,

Quan Chen

Publication year - 2018

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00030.2017

Subject(s) - mitophagy , cardioprotection , ischemia , platelet , microbiology and biotechnology , reperfusion injury , organelle , mechanism (biology) , medicine , autophagy , chemistry , cardiology , biology , biochemistry , apoptosis , philosophy , epistemology

Mitophagy, a process that selectively removes damaged organelles by autolysosomal degradation, is an early cellular response to ischemia. Mitophagy is activated in both cardiomyocytes and platelets during ischemia/reperfusion (I/R) and heart disease conditions. We focus on the molecular regulation of mitophagy and highlight the role of mitophagy in cardioprotection.

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