ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases | Zendy

Ramy E. Abdelhamid | Zendy; Kathleen A. Sluka | Zendy

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ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases

Author(s) -

Ramy E. Abdelhamid,

Kathleen A. Sluka

Publication year - 2015

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00030.2015

Subject(s) - nociceptor , inflammation , hyperalgesia , medicine , nociception , rheumatoid arthritis , musculoskeletal pain , arthritis , joint pain , chronic pain , acid sensing ion channel , neuroscience , physical therapy , physical medicine and rehabilitation , receptor , biology , ion channel

Chronic musculoskeletal pain is debilitating and affects ∼ 20% of adults. Tissue acidosis is present in painful musculoskeletal diseases like rheumatoid arthritis. ASICs are located on skeletal muscle and joint nociceptors as well as on nonneuronal cells in the muscles and joints, where they mediate nociception. This review discusses the properties of different types of ASICs, factors affecting their pH sensitivity, and their role in musculoskeletal hyperalgesia and inflammation.

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