The Difference δ-Cells Make in Glucose Control | Zendy

Mark O. Huising | Zendy; Talitha van der Meulen | Zendy; Jessica L. Huang | Zendy; Mohammad S. Pourhosseinzadeh | Zendy; Glyn M. Noguchi | Zendy

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The Difference δ-Cells Make in Glucose Control

Author(s) -

Mark O. Huising,

Talitha van der Meulen,

Jessica L. Huang,

Mohammad S. Pourhosseinzadeh,

Glyn M. Noguchi

Publication year - 2018

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00029.2018

Subject(s) - set point , glycemic , secretion , islet , glucagon , insulin , negative feedback , endocrinology , medicine , microbiology and biotechnology , biology , delta cell , physics , quantum mechanics , control engineering , voltage , engineering

The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β-cells that determines the blood glucose set point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.

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