Bypassing Border Control: Nuclear Envelope Rupture in Disease | Zendy

Gaëlle Houthaeve | Zendy; Joke Robijns | Zendy; Kevin Braeckmans | Zendy; Winnok H. De Vos | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Bypassing Border Control: Nuclear Envelope Rupture in Disease

Author(s) -

Gaëlle Houthaeve,

Joke Robijns,

Kevin Braeckmans,

Winnok H. De Vos

Publication year - 2017

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00029.2017

Subject(s) - interphase , microbiology and biotechnology , cytoplasm , organism , dna damage , disease , biology , genome instability , cell , mechanism (biology) , genetics , medicine , dna , pathology , physics , quantum mechanics

Recent observations in laminopathy patient cells and cancer cells have revealed that the nuclear envelope (NE) can transiently rupture during interphase. NE rupture leads to an uncoordinated exchange of nuclear and cytoplasmic material, thereby deregulating cellular homeostasis. Moreover, concurrently inflicted DNA damage could prime rupture-prone cells for genome instability. Thus, NE rupture may represent a novel pathogenic mechanism that has far-reaching consequences for cell and organism physiology.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research