Exosomal miRNAs in Heart Disease | Zendy

Claudio Iaconetti | Zendy; Sabato Sorrentino | Zendy; Salvatore De Rosa | Zendy; Ciro Indolfi | Zendy

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Exosomal miRNAs in Heart Disease

Author(s) -

Claudio Iaconetti,

Sabato Sorrentino,

Salvatore De Rosa,

Ciro Indolfi

Publication year - 2015

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00029.2015

Subject(s) - microvesicles , microrna , myocardial infarction , biology , heart failure , disease , intracellular , gene expression , regulation of gene expression , bioinformatics , non coding rna , gene , computational biology , medicine , microbiology and biotechnology , pathology , genetics

Micro-RNAs (miRNAs) are small noncoding RNAs involved in the posttranscriptional regulation of gene expression. Exosomes have recently emerged as novel elements of intercellular communication in the cardiovascular system. Exosomal miRNAs could be key players in intercellular cross-talk, particularly during different diseases such as myocardial infarction (MI) and heart failure (HF). This review addresses the functional role played by exosomal miRNAs in heart disease and their potential use as new biomarkers.

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