HIV and Cardiovascular Disease: Role of Immunometabolic Perturbations | Zendy

Eman Teer | Zendy; M. Faadiel Essop | Zendy

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HIV and Cardiovascular Disease: Role of Immunometabolic Perturbations

Author(s) -

Eman Teer,

M. Faadiel Essop

Publication year - 2017

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00028.2017

Subject(s) - disease , human immunodeficiency virus (hiv) , medicine , biology , immunology , virology

The successful rollout of anti-retroviral therapy ensured that HIV is increasingly managed as a chronic condition. HIV-positive persons are therefore exhibiting increased cardiovascular complications. This review focuses on the emerging role of ”immunometabolism” within the context of HIV-related immune dysregulation and cardiovascular disease onset. Here, persistent immune activation contributes to pathophysiological perturbations during early infection, resulting in immune cell metabolic reprogramming and the activation of coagulation pathways in HIV-positive individuals.

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