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Energy Constraint as a Novel Mechanism Linking Exercise and Health
Author(s) -
Herman Pontzer
Publication year - 2018
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00027.2018
Subject(s) - mechanism (biology) , energy expenditure , downregulation and upregulation , physical activity , reproduction , constraint (computer aided design) , medicine , physical medicine and rehabilitation , biology , ecology , physics , engineering , genetics , gene , mechanical engineering , quantum mechanics
Humans and other species adapt dynamically to changes in daily physical activity, maintaining total energy expenditure within a narrow range. Chronic exercise thus suppresses other physiological activity, including immunity, reproduction, and stress response. This exercise-induced downregulation improves health at moderate levels of physical activity but can be detrimental at extreme workloads.

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