Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics | Zendy

Lucas Smith | Zendy; Sang-Kyun Cho | Zendy; Dennis E. Discher | Zendy

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Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics

Author(s) -

Lucas Smith,

Sang-Kyun Cho,

Dennis E. Discher

Publication year - 2017

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00026.2017

Subject(s) - extracellular matrix , microbiology and biotechnology , cytoskeleton , stem cell , matrix (chemical analysis) , extracellular , cellular differentiation , adhesion , biology , cell adhesion , cell , chemistry , gene , genetics , organic chemistry , chromatography

Stem cells mechanosense the stiffness of their microenvironment, which impacts differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix (ECM) stiffness is clearly transduced into gene expression via adhesion and cytoskeleton proteins that tune fates. Cytoskeletal reorganization of ECM can create heterogeneity and influence fates, with fibrosis being one extreme.

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