Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging
Author(s) -
Walter A. Rocca,
Liliana Gazzuola Rocca,
Carin Y. Smith,
Brandon R. Grossardt,
Stephanie S. Faubion,
Lynne T. Shuster,
James L. Kirkland,
Nathan K. LeBrasseur,
Marissa J. Schafer,
Michelle M. Mielke,
Kejal Kantarci,
Elizabeth A. Stewart,
Virginia M. Miller
Publication year - 2018
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00024.2018
Subject(s) - hormone , estrogen , oophorectomy , somatic cell , physiology , medicine , menopause , ovary , biology , endocrinology , hysterectomy , pathology , biochemistry , gene
Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.
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