Fibroblasts and the Ground They Walk On | Zendy

Daniel J. Tschumperlin | Zendy

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Fibroblasts and the Ground They Walk On

Author(s) -

Daniel J. Tschumperlin

Publication year - 2013

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00024.2013

Subject(s) - extracellular matrix , fibroblast , fibrosis , wound healing , microbiology and biotechnology , contraction (grammar) , matrix (chemical analysis) , chemistry , biology , biophysics , pathology , medicine , immunology , biochemistry , endocrinology , in vitro , chromatography

Fibroblast migration is essential to normal wound healing and pathological matrix deposition in fibrosis. This review summarizes our understanding of how fibroblasts navigate 2D and 3D extracellular matrices, how this behavior is influenced by the architecture and mechanical properties of the matrix, and how migration is integrated with the other principle functions of fibroblasts, including matrix deposition, contraction, and degradation.

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