Oxygen Sensing and Homeostasis | Zendy

Nanduri R. Prabhakar | Zendy; Gregg L. Semenza | Zendy

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Oxygen Sensing and Homeostasis

Author(s) -

Nanduri R. Prabhakar,

Gregg L. Semenza

Publication year - 2015

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00022.2015

Subject(s) - homeostasis , hypoxia (environmental) , carotid body , biology , oxygen , oxygen metabolism , hypoxia inducible factors , microbiology and biotechnology , receptor , neuroscience , chemistry , biochemistry , gene , electrophysiology , organic chemistry

The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.

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