Open AccessScaling of Motor Output, From Mouse to Humans
Author(s) -
Marin Manuel,
Matthieu K. Chardon,
Vicki M. Tysseling,
C. J. Heckman
Publication year - 2018
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00021.2018
Subject(s) - neuroscience , scaling , biology , motor activity , motor neuron , mathematics , endocrinology , geometry , spinal cord
Appropriate scaling of motor output from mouse to humans is essential. The motoneurons that generate all motor output are, however, very different in rodents compared with humans, being smaller and much more excitable. In contrast, feline motoneurons are more similar to those in humans. These scaling differences need to be taken into account for the use of rodents for translational studies of motor output.
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