Central Dogma or Central Debate? | Zendy

Denis Noble | Zendy

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Central Dogma or Central Debate?

Author(s) -

Denis Noble

Publication year - 2018

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00017.2018

Subject(s) - biology , inheritance (genetic algorithm) , confusion , genetics , evolutionary biology , gene , psychology , psychoanalysis

The Central Dogma of molecular biology has been widely misinterpreted to be a modern version of the Weismann Barrier. This confuses cellular-level inheritance with DNA inheritance and is therefore incorrect. The consequences for biology generally and for physiology in particular are profound. Removing the confusion completely alters our understanding of the relationship between physiology and evolutionary biology. The Weismann Barrier is permeable, and organisms are capable of transmitting non-DNA inheritance.

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