Transmission of Metabolic Dysfunction Across Generations | Zendy

Kathleen Jaeger | Zendy; Jessica L. Saben | Zendy; Kelle H. Moley | Zendy

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Transmission of Metabolic Dysfunction Across Generations

Author(s) -

Kathleen Jaeger,

Jessica L. Saben,

Kelle H. Moley

Publication year - 2016

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00017.2016

Subject(s) - epigenome , offspring , epigenetics , biology , dna methylation , disease , genetics , genome , genetic predisposition , evolutionary biology , pregnancy , gene , medicine , gene expression

Recent human and animal studies investigating the roles of the genome, epigenome, and environmental cues have identified associations between offspring predisposition to life-long obesity/metabolic disease and epigenetic modifications such as DNA methylation. This review explores the mechanisms by which maternal exposures impair the health of not only the next generation but also potentially future generations of offspring.

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