Lactic Acid: No Longer an Inert and End-Product of Glycolysis | Zendy

Shiren Sun | Zendy; Heng Li | Zendy; Jianghua Chen | Zendy; Qi Qian | Zendy

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Lactic Acid: No Longer an Inert and End-Product of Glycolysis

Author(s) -

Shiren Sun,

Heng Li,

Jianghua Chen,

Qi Qian

Publication year - 2017

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00016.2017

Subject(s) - lactic acid , glycolysis , microbiology and biotechnology , immune system , wound healing , biochemistry , metastasis , energy metabolism , chemistry , biology , cancer , cancer research , metabolism , bacteria , immunology , endocrinology , genetics

For decades, lactic acid has been considered a dead-end product of glycolysis. Research in the last 20+ years has shown otherwise. Through its transporters (MCTs) and receptor (GPR81), lactic acid plays a key role in multiple cellular processes, including energy regulation, immune tolerance, memory formation, wound healing, ischemic tissue injury, and cancer growth and metastasis. We summarize key findings of lactic acid signaling, functions, and many remaining questions.

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