Integration of ChREBP-Mediated Glucose Sensing into Whole Body Metabolism
Author(s) -
Floriane Baraille,
Julien Planchais,
Renaud Dentin,
Sandra Guilmeau,
Catherine Postic
Publication year - 2015
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00016.2015
Subject(s) - carbohydrate metabolism , carbohydrate responsive element binding protein , metabolism , biology , chemistry , biochemistry , transcription factor , gene
Since glucose is the principal energy source for most cells, many organisms have evolved numerous and sophisticated mechanisms to sense glucose and respond to it appropriately. In this context, cloning of the carbohydrate responsive element binding protein has unraveled a critical molecular link between glucose metabolism and transcriptional reprograming induced by glucose. In this review, we detail major findings that have advanced our knowledge of glucose sensing.
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